Welcome to Kemmx Corporation

Kemmx is committed to bringing novel pain and anti-inflammatory medicines to those who suffer from chronic pain. 

Kemmx has identitified small molecules that penetrate the skin to provide local pain relief.

Kemmx has been supported by the NIH  Bridging Interventional Development Gaps (BrIDGs) program: https://ncats.nih.gov/bridgs/projects/complete/small-molecule-treatment-rheumatoid-arthritis 

Pain relief by glutaminase inhibition:  US Patent 7,288,246

AND 

Innovative topical medicine for surgical sites that has Triple A function: 1) Antibiotic; 2) Analgesic; 3) Anti-inflammatory

• Hoffman, E.M., R. Schechter, K.E. Miller, Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat. Neuroscience Lett. 472(3):157-160, 2010. PMID:20132864.
• Miller K.E., E.M. Hoffman, M. Sutharshan, R. Schechter, Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms. Pharmacology & Therapeutics 130(3):283-309, 2011. PMID:21276816. DOI: 10.1016/j.neulet.2010.01.066
• Miller K.E., J. Balbás, R.L. Benton, T.S. Lam, K.M. Edwards, R.M. Kriebel, and R. Schechter, Glutaminase immunoreactivity and enzyme activity is increased in the rat dorsal root ganglion following inflammation. Special issue: Primary Afferent Nociceptor as a Target for the Relief of Pain. Pain Research and Treatment 2012:414697, 2012; PMID: 22229088. DOI: 10.1155/2012/414697
• Crosby, H.A., M. Ihnat, and K.E. Miller, Evaluating the toxicity of the analgesic glutaminase inhibitor 6-diazo-5-oxo-L-norleucine in vitro and on rat dermal skin fibroblasts. MOJ Toxicology 1(1):00005. DOI: 10.15406/mojt.2015.02.00005, 2015.
• Crosby H.A., D. Spencer, M. Ihnat, and K.E. Miller, Glutaminase and vesicular glutamate transporter type 2 Immunoreactivity and expression in rat sacral level dorsal root ganglia following a surgical tail incision. Pharm Pharmacol Int J 2(3): 00023. DOI: 10.15406/ppij.2015.02.00023, 2015.
• Hoffman, E.M., Z. Zhang, R. Schechter, and K.E. Miller, Glutaminase increases in rat dorsal root ganglion neurons after unilateral adjuvant-induced hind paw inflammation. Special Issue: Role and Regulation of Glutamate Metabolism. Biomolecules 6(1), 10-24; doi:10.3390/biom6010010, 2016.
• Crosby, H.A. and K.E. Miller, Evaluating the analgesic effect of the GLS inhibitor 6-diazo-5-oxo-l-norleucine in vivo. Pharm Pharmacol Int J 3(3): 00055. doi: 10.15406/ppij.2015.03.00055, 2016.
• Kulkarni R.M., E.W. Dakoulas, K.E. Miller, P.S. Terse, Evaluation of Genetic toxicity of 6-diazo-5-oxo-L-norleucine. Toxicology Mechanisms and Methods, 29:1-27, 2017. doi: 10.1080/15376516.2017.1333552.

linkedin: https://www.linkedin.com/in/kenneth-miller-9bbba713/

researchgate: https://www.researchgate.net/profile/Kenneth_Miller5